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In addition, we explored the crosstalk between macrophages and endothelial cells using in vitro co-cultures
Once reconstituted, however, the shelf life drops to approximately 28 to 30 days, making it comparable to pre-mixed formulations
The effect is dose-dependent and reversible (after discontinuation, pigmentation subsides over weeks to months)
As of April 2026, Zepbound (tirzepatide) appears on the formulary with the following restrictions: Covered indications: Type 2 diabetes mellitus as an adjunct to diet and exercise Must be prescribed by a TRICARE-authorized provider Requires prior authorization regardless of plan type Subject to step therapy requirements (metformin, sulfonylureas, or other first-line agents must be tried first) Excluded indications: Obesity or weight management in patients without type 2 diabetes Overweight status (BMI 25 to 29.9) Metabolic syndrome without diagnosed diabetes Prediabetes (HbA1c 5.7% to 6.4%) Cardiovascular risk reduction in non-diabetic patients The distinction matters because Zepbound is FDA-approved for both chronic weight management (approved December 2023) and type 2 diabetes (approved May 2022 under the brand name Mounjaro)
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