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This precise delivery mechanism may at last lead to an increased therapeutic index of the corresponding payload cytotoxic compound, limiting secondary effects at equivalent systemic doses
This concept is further supported by large-scale observational data (Mller et al., Diabetes Obes Metab J, 2022) showing no increased PTC risk in patients, reinforcing the safety profile
However, there are effective strategies to manage and potentially mitigate this side effect
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