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What has become equally clear however, is that autoimmune inflammation is only one part of the equation, with an underlying cytodegeneration beginning early and continuing relentlessly throughout the course of the disease

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Skin sensitivity: an emerging signal Skin burning and abnormal touch sensitivity (dysesthesia) appears as a dose-related, reversible signal in two case series and post-market surveillance. Trials did not pre-specify it, and the tirzepatide label does not list it