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While SGLT2 inhibitors and GLP-1 receptor agonists carry a low hypoglycemia risk when used as monotherapy in type 2 diabetes, their additive glucose-lowering effects can precipitate hypoglycemia when used in combination with insulin
A smaller study in twins showed that in monozygotic pairs discordant for BMI and liver fat the GLP-1 secretion was reduced at 60 min during an OGTT [45]
Published preclinical work associates it with collagen and decorin regulation and with broad gene-expression shifts across ECM-related markers
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