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In humans and animals, it has shown no toxicity and good tolerability [23, 28]
However, it is a poorer precursor as it requires methyl ester modification for transport into the cell 37,38
NMN supplementation in mice also improved mitochondrial morphology through DRP1, and reduced ROS through antioxidant response expression 113
Studies have indicated that AOD-9604 can stimulate lipolysis without affecting insulin or IGF1 levels, suggesting that it may not lead to the development of diabetes or glucose intolerance
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