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WD increased inflammation in the amygdala and ventral hippocampus in a sex-specific manner and GE2 reduces inflammation in the hippocampus and amygdala dependent on diet and sex, respectively In the present study, we found sex- and site-specific increases in inflammation in response to WD exposure, in which males presented with elevated inflammation in the ventral hippocampus, whereas females presented with increased inflammation in the amygdala