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Tirzepatide is a dual GIP/GLP-1 receptor agonist, activating two incretin pathways, while semaglutide is a single GLP-1 receptor agonist
A notable publication in the New England Journal of Medicine found that patients taking semaglutide had a higher rate of diabetic retinopathy complications compared to those on a placebo
Notably, few data (only with semaglutide) were available for patients with BMI over 40 kg m 2 , and none could be retrieved for those with BMI 2730 kg m 2
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