Lai JJ, Chau ZL, Chen SY, Hill JJ, Korpany KV, Liang NW, Lin LH, Lin YH, et al
How hepatocytes are sensitized to TNF-induced hepatotoxicity in the setting of NAFLD remains unknown
Because nicotinamide would otherwise re-enter the NAD+ salvage pathway through NAMPT and NMN, NNMT activity sits at a junction between cellular methylation capacity and NAD+ regeneration, which is why the enzyme became a target after Kraus and colleagues (Nature, 2014) reported the consequences of antisense Nnmt knockdown in white adipose tissue and liver
This study, which used confocal laser scanning microscopy, showed significant improvement with the collagen treatment in the structural aspects of facial skin, while no improvements were found in the placebo group