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The changes were gradual but real

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GHRH(129)NH 2 had a disappearance half-time of 4.3 1.4 min and a metabolic clearance rate of 39.7 3.9 mL/kgmin during constant IV infusion in normal men values from the unmodified GHRH(129)NH 2 comparator arm of a study whose primary subject was the D-Ala 2 analog [6]