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How Tirzepatide Works: The Dual GIP + GLP-1 Mechanism Per FDA labeling, tirzepatide is an agonist of both the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor
When symptoms such as low energy, poor sleep, mood changes, low libido, or persistent weight gain are present, evaluating hormone health may provide additional insight into factors affecting weight management
This approach reflects the success seen with SGLT2 inhibitors, which have demonstrated significant cardioprotective and anti-inflammatory effects in conditions such as SLE, leading to their integration into clinical practice for autoimmune diseases (83)
May be suitable for those already managing type 2 diabetes, as Rybelsus is FDA-approved for diabetes treatment and may help with weight loss in these individuals
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