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that bone loss was most pronounced in weight-bearing skeletal sites, with no significant changes in non-weight-bearing areas such as the radius, suggests that mechanical unloading may be a key driver of bone resorption rather than a direct pharmacologic effect of GLP-1 receptor activation
In a Phase 2 clinical trial published in The Lancet, the drug significantly improved blood-sugar control and reduced body weight in people with Type 2 diabetes compared with a placebo
Yu F, Zhang Y, Yang C, Li F, Qiu B, Ding W
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