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Second, improvements in IR and glycaemic indices are most apparent in higher-burden phenotypes, particularly in women with impaired glucose tolerance/prediabetes or related metabolic comorbidities, where changes in HOMA-IR, fasting glucose and OGTT profiles are more pronounced and may plausibly reduce periconception metabolic risk
Stratum corneum modulation by chemical enhancers and lipid nanostructures: implications for transdermal drug delivery
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Proper dosing and monitoring minimize these concerns
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