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Prior to the targeted synthesis and study of these peptides, research into growth hormone modulation and metabolic signaling relied largely on less specific hormonal interventions and generalized secretagogues
Timing Baseline Marker Fasting glucose Why it matters Gives a current glucose snapshot during GH-axis protocols
doi: 10.1016/j.rbmo.2019.03.099, 222
Of note, exendin-4 was serendipitously discovered in the saliva of the Gila monster ( Heloderma suspectum ) and was revealed to be a GLP-1 analog that is resistant to DPP-4 action in 1992, even before the mechanism of GLP-1 degradation was identified [7]
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