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ALT responders were significantly younger than ALT non-responders (50.7 12.1 years vs
PMID: 248 SajiSMcArthurHLIgnatiadisMBaileyAEl-AbedSBrandaoMet al
2D and Table S1), which may be attributed to rigidification of the GSH surface ligands due to the HIP with DDA
R This pathway is the primary defense against: Aflatoxin B1 (a carcinogenic mycotoxin produced by Aspergillus) Cadmium Epoxides (reactive Phase I intermediates from polycyclic aromatic hydrocarbons) Lipid peroxidation products (4-hydroxynonenal, malondialdehyde) Mercury (organic and inorganic forms) Reactive oxygen species (ROS) and reactive nitrogen species (RNS) GSTs exist in three locations: cytosolic (the largest class, with alpha, mu, pi, theta, sigma, omega, and zeta subfamilies), mitochondrial (kappa class), and microsomal (MAPEG family)
