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The trial did have a conflict of interest in that it received support from a company that provides Setria, but it was also a randomized, double-blinded, and placebo-controlled trial with sound methods
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Future research should focus on refining these treatment modalities and expanding comparative studies to optimize B12 deficiency management strategies effectively
Interestingly, we see marginal release of cytochrome c following 5FU and a transient dip in MOMP, but no enhanced difference in sensitivity to BH3-mimetics or increase in ATF4 expression or predicted activity in RNA-seq analysis (data not shown)
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