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So far, semaglutide (Wegovy) shows the most significant weight loss among approved GLP-1s: Average weight loss: 15 percent or more of body weight over time Administered once weekly Tirzepatide (Mounjaro), though not a pure GLP-1, has shown even greater weight loss in trials and was approved by the FDA specifically for weight management under the name Zepbound
NICE guidance provides clear recommendations for GLP-1 use, which focus exclusively on glycaemic control in type 2 diabetes (NG28) and weight management in obesity (TA875 for semaglutide, TA664 for liraglutide)
But I told myself, Even if I lose 10 pounds, I will feel better
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