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This binding mode is similar to GSH_c, primarily involving chelation with copper ions and interaction with E184 to determine the binding mode
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Not having enough can cause serious problems like nerve damage and memory issues
PE-22-28 (Mini-Spadin) blocks TREK-1 potassium channels with ~100-fold greater potency than its parent compound, demonstrating BDNF upregulation, rapid neurogenesis within 4 days, and cognitive benefits in stroke models (Djillani et al., 2017 in Frontiers in Pharmacology)
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