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Reduced CII activity has consequences for central carbon metabolism because CII is involved in the conversion of succinate to fumarate within the TCA cycle 73

Efficacy and safety of glucagon-like peptide-1 receptor agonists in type 2 diabetes: a systematic review and mixed-treatment comparison analysis

Global NASH Council, American Association for the Study of Liver Diseases (AASLD), EASL | The Home of Hepatology, Canadian Association for the Study of the Liver, European Liver Patients' Association - ELPA, Global Liver Institute, Priti Chawla, Obesity Matters, American Diabetes Association Fatty Liver Alliances Post GLP-1 receptor agonists (GLP-1RAs) show promise in managing metabolic dysfunction-associated steatotic liver disease (MASLD) by reducing hepatic steatosis, resolving MASH, and mitigating fibrosis progression

No human evidence confirms this risk, but the mechanism warrants awareness