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Notably, if the Nrf2-ARE/HO-1 axis metabolic pathway is stimulated in melanocytes, the ability to remove ROS in these cells is restored (Muthusamy et al., 2012) and chronic PE ( Acute PE also increases signaling pathways of the enzymatic antioxidant system by NADPH-oxidase NF-B (Qi et al., 2020)

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