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Ozempic is whats known as a glucagon-like peptide-1 (GLP-1) receptor agonist, a class of drugs that also includes liraglutide (Victoza), dulaglutide (Trulicity), and exenatide (Bydureon)
They increase sodium excretion through the kidneys, which pulls water along with it
Such multifaceted regulatory networks, compounded by tissue-specific variations in calcium handling, substantially complicate the therapeutic targeting of GLP-1RAs