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The GSTK1/RETREG1 complex conferred protection against diabetic tubular damage and kidney injury via modulating ER stress and apoptosis through the induction of reticulophagy, thereby revealing that maintaining ER homeostasis is crucial for the control of apoptosis (72, 111)

Experiments both in vitro and vivo have shown that metformin attenuates the progression of DKD by suppressing renal inflammation, oxidative stress, and fibrosis (180)

SARS-CoV-2 infection generates massive ROS production and the excessive oxidative damage is responsible for cytokine storm, undermined immunity, tissue damage and severe lung disease causing ARDS and death (Silvagno et al., 2020)

This means it hits IGF-1 receptors directly and rapidly, creating intense but brief anabolic signaling in whatever tissue you inject it into