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Methods We identified genetic proxies of the effect of GLP-1R, GIPR, and GCGR by combining Mendelian randomization (MR), Bayesian colocalization, and linkage disequilibrium (LD) analyses
For type 2 diabetes (NICE NG28), GLP-1 receptor agonists are generally considered after metformin-based therapy has proven insufficient, and can be initiated in primary care according to local formularies and prescribing arrangements
Wegovy, the higher-dose semaglutide specifically approved for weight management, has more limited availability
doi: 10.1097/mib.0000000000000847 54 LebrunLJLenaertsKKiersDBarrosJ-PGuernLNPlesnikJet al
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