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GLP-1 analogs were administered for 21 days to MC4R KO mice and compared their efficacy
The primary safety consideration is timing
Propionate-induced gut hormone release is attenuated in FFA2 / primary murine L cells To evaluate the role of FFA2 in mediating propionate-induced PYY and GLP-1 secretion, we examined the effect of propionate on gut hormone secretion from primary colonic cultures from FFA2-deficient mice (FFA2 / )
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