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Vitamin B12 deficiency is primarily caused by autoimmune pernicious anemia, dietary restrictions such as vegetarian or vegan diets, and medical conditions that interfere with absorption such as celiac and Crohns disease
Cobalamin coenzyme forms are not likely to be superior to cyanoand hydroxylcobalamin in prevention or treatment of cobalamin deficiency
In addition, B12 deficiency-associated fatigue is often accompanied by other symptoms such as numbness and tingling, cognitive impairment (memory and concentration problems), mood swings (depression), skin changes (pale skin), shortness of breath, or fast heart rate
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