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The MOTS-C Connection MOTS-C activates AMPK through a mitochondrial stress pathway, improving fat oxidation and cellular energy efficiency

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[12] Beyond that specific episode, GH secretagogues generally can affect glucose metabolism and insulin sensitivity: raising GH tends to oppose insulin action, and studies of oral ghrelin-mimetic secretagogues in older adults have documented measurable effects on glucose handling alongside their GH and IGF-I elevation

All these data indicate that GLP-1RA might prevent nigral cells from the neurodegenerative process associated with PD by acting on different pathways [10, 48]