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Among our participants, nausea incidence was comparable to the lowest maintenance dose of tirzepatide, while fewer reported constipation or diarrhoea ( In a randomized controlled trial invastigating the efficacy of subcutaneous semaglutide injections at a dose of 2.4 mg weekly for obesity treatment, participants experienced an average weight loss of 15% and a BMI reduction by an average of 5.5 kg/m after 68 weeks ( In the PIONEER 1 study ( Additionally, in the OASIS 1 trial ( According to our data and published data on other medications, we can indirectly infer that oral semaglutide at a dose of 14 mg is associated with less weight loss and a smaller reduction in BMI compared to tirzepatide at all maintenance doses, subcutaneous semaglutide at 2.4 mg weekly, and oral semaglutide at 50 mg daily
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However, data about VAT or SAT and appendicular or trunk fat mass are lacking in PWS infants, making it difficult to determine if PWS patients are born with these characteristics
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