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One of the most abundantly expressed genes in ovarian tumours and tumour cell lines was glutathione S -transferase P1 ( GSTP1 , EC 2.5.1.18), a polymorphic phase II drug-metabolising enzyme, which conjugates the antioxidant tri-peptide glutathione with many toxic hydrophobic and electrophilic xenobiotics to facilitate elimination (reviewed by Hayes and Pulford, 1995)
Notably, GHKs gene expression signature was found to reverse 70% of the genes in a signature for metastasis-prone colon cancer (Hong et al.), and to shift gene expression in COPD lung tissue from a destructive/inflammatory pattern toward healthy remodeling
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Whether GLP-1-induced weight loss accelerates or delays menopause hasnt been studied
