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If the observed benefit of GLP-1 receptor agonists disappears or weakens meaningfully when compared with another contemporary metabolic therapy, then the story becomes less about a unique anticancer effect and more about broader metabolic optimization, comparator selection, or residual differences between treatment populations
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In a retrospective study completed by Nadeem et al., it was shown that GLP-1 RAs are associated with an overall fourfold increase in the retention of gastric contents in both diabetic and non-diabetic patients ( p -value 0.8 mL/kg of gastric fluid content (measured from the aspiration/suction canister)
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