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In a separate study, a combination of human stem cell transplantation and antidiabetic drugs was highly effective in improving body weight and glucose metabolism in a mouse model of type 2 diabetes (Bruin 2015)

In a pre- and postnatal development study in pregnant cynomolgus monkeys, subcutaneous doses of 0.015, 0.075 and 0.15 mg/kg twice weekly (1.3-, 6.4- and 14-fold the MRHD) were administered from Gestation Day 16 to 140