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Since B12 is processed in the liver, excessive amounts could potentially lead to complications in severe liver conditions
Its also recommended to be cautious in people on certain medications like levodopa (without carbidopa), as mentioned, or those with specific medical conditions, but these are matters of caution rather than strict contraindications
Inositol particularly myo-inositol has been studied more seriously in insulin resistance and PCOS than in general weight loss, and it is not approved to treat any mental health condition despite the serotonin connection appearing in a lot of clinic copy
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