tirzepatide png Microdosing Tirzepatide 2.5mg: Weight Loss Starter

In the proximal small intestine (duodenum and jejunum), where conjugated primary BAs predominate, FXR expression is relatively low, while ASBT (apical sodium-dependent BA transporter) is absent, limiting BAs uptake ( In the colon, where microbial deconjugation and dehydroxylation generate secondary BAs, TGR5 becomes the dominant receptor

Finally, humans with ulcerative colitis have increased fecal bile acid concentrations, and decreased concentrations of fecal bile acid metabolites, suggesting that bile acid metabolism may play a role in ulcerative colitis, or, at least, is a result of the disease

This is why EMAs use of broad data sources and real-world surveillance made the regulatory finding more robust

Intestinal Res