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VEGF, through binding to VEGF receptors (VEGFR), activates PI3K/AKT and MAPK/ERK pathways, which are vital for endothelial cell survival, migration, and proliferation

Availability of data and materials All data generated or analysed during this study are included in this published article

mTOR signaling factors downstream of IGF1R play key roles in the regulation of cancer cell metabolism, lipid and protein synthesis and they are responsible for several metabolic adaptations ( In vitro studies, over-expression of the IGF1R has been identified as a typical hallmark of many types of tumors (Werner et al., 2012)

It contains Coenzyme Q10, L-Carnitine L-Tartrate, Zinc, and Selenium, which help in reducing oxidative stress