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How to Use: Typically prescribed as a once-weekly injection given on the same day each week, with or without food

Typically appears as a raised, dome-shaped bump May be red, pink, brown, or black in color Often lacks the classic warning signs (asymmetry, border irregularity, color variation) Most commonly found on sun-exposed areas, especially the head and neck Can develop anywhere on the body Biological behavior Nodular melanoma often enters the vertical growth phase immediately This means it grows downward into deeper layers of the skin early, increasing the risk of metastasis Rapid growth is the most important clinical clue Importance Nodular melanoma can be harder to recognize because it does not always follow typical melanoma warning signs

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The primary concern is increased gastrointestinal discomfort or irritation, as both medications can affect the digestive system