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What the Authoritative Sources Say About B12 Deficiency and Supplementation The National Institutes of Health Office of Dietary Supplements publishes the most thorough citation-backed overview of vitamin B12 its role in red blood cell formation and neurological function, the populations most at risk for deficiency (older adults, people on long-term metformin or proton pump inhibitors, vegetarians and vegans, people who have had gastric bypass surgery), and the recommended daily intake at each life stage
Interestingly, this has not discouraged multiple research groups testing cysteine prodrugs, such as N-acetylcysteine (NAC), as supplements to increase GSH levels
The former, often lacking in overt hemolysis and Heinz bodies, may be more of a bilirubin accumulation and clearance problem
Biosci Rep (2019) 39(7):3245-58
