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This is the phase where serious commercialization planning starts, including identifying a Phase III customer

If deficiency or tissue utilization concerns arise, functional markers like methylmalonic acid (MMA) and homocysteine levels may offer additional context (source: Harvard T.H

Furthermore, while the multi-targeted (polypharmacological) mechanisms are advantageous for a complex disease, they complicate the precise attribution of therapeutic effects to specific structural features or isolated pathways, hindering the development of precisely defined therapeutics

New insights into the genetic etiology of Alzheimers disease and related dementias