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Younossi noted that pharmacotherapy must always be accompanied by lifestyle modification to minimize ultra processed foods, high sugary drinks, and alcohol. Funding was provided by the Foundation for Liver and Gastrointestinal Research, Rotterdam, the Netherlands
These predispositions do not predict exact medication response but may help providers contextualize why certain dose ranges or adjunct strategies feel more effective for individual patients
There is baseline secretion of GLP-1 even during fasting (510 pm), but postprandially induced production increases with meal size (1030 pm)
When patients stop tirzepatide, weight comes back for the majority not because they are doing anything wrong, but because the biological environment that drives weight regain is restored when the medication is removed
