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Collagen synthesis pathways demonstrate coordinated regulation under dual compound treatment
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they describe investigational findings and do not represent therapeutic outcomes or approved indications in humans
Furthermore, CD4+ and CD8+ T cells in the TME often exhibit functional impairment, inactivation, or exhaustion, and frequently co-express multiple immune checkpoint molecules, such as PD-1, lymphocyte activation gene 3, and T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3)
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