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Cotadutide (medi0382), a dual receptor agonist with glucagon-like peptide-1 and glucagon activity, modulates hepatic glycogen and fat content
Thereby, PI3K and AKT transcription was downregulated 1.7- and 2-fold, respectively, whereas PGC-1 transcripts were increased 7-fold and AKT phosphorylation was reduced by 3550%
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