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Collectively, these results suggest that OTUD5 is modified with K29 linkages by TRIP12 and then with K48 linkages by UBR5, resulting in the conjugation of K29/K48 branched ubiquitin chains in which the majority of K48-linkages are added to the distal sides of K29-linked chains

Presented for research literature review only Lapenna D (2023)

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15,16 On the other hand, TRX reductase (TRXR) utilizes NADPH as an electron donor to maintain the reduced form of TRX, which contributes to scavenge H 2 O 2 and reduce ribonucleotide reductase (RNR) for DNA synthesis