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Benayoun, B
In hepatic encephalopathy, elevated blood ammonia resulting from liver failure disrupts the BBB via the Nuclear Factor -Light-Chain-Enhancer of Activated B Cells (NF-B) pathway, impairs mitochondrial function in astrocytes, and perturbs neurotransmitter balance through potassium dysregulation [67]
Tumour cells may be identified by novel cell surface receptors, increased metabolic rate, and, in some cases, disordered vascularization all of which can be utilized to selectively deliver drugs
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