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Multiple molecular mechanisms, activated by inflammatory mediators, contribute to the progression of HS.34,35 The prevalence of DT2 is higher in subjects with HS than in the general population.36 HS is also associated with other conditions traditionally linked with obesity, such as metabolic syndrome, polycystic ovarian syndrome, and inflammatory bowel disease,3739 and patients with HS are exposed to higher CVR than the general population.40 Obesity negatively impacts the response of patients to the main treatments for HS (Table S1 additional information).15 Advantages associated with weight loss in patients with obesity and psoriasis or hidradenitis suppurativa In addition to better response to treatments for inflammatory dermatoses, other arguments justify the desirability of patients with obesity and PsO or HS to lose weight
2026, Lifted Health
Taken together, these outcomes are consistent with a scenario in which NF-Bdependent inflammatory activity is dampened, Nrf2-mediated antioxidant defenses are strengthened, and TGF-/Smad signaling is reduced
doi: 10.2174/138945012798868434 21 ZhangYSunBFengDHuHChuMQuQet al
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