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Transition planning between vial sizes Most researchers use 10mg vials for phases 1-2 (1-2mg weekly, consuming about 4-8mg per 4-week block), then switch to 20mg or 30mg vials for phases 3-5 when weekly consumption increases significantly

Immunohistochemistry confirmed increased intratumoral GZMB and CD69 T-cell densities, supporting effective activation of T-cell effector function [100]