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Description

Participants in the study were administered semaglutide at a starting dose of 0.25 mg, eventually increasing it over 16 weeks, along with a reduced-calorie diet and physical activity

Shea TC, Kelley SL, Henner WD

Tirzepatide's SURMOUNT-1 curve flattened earlier at a lower ceiling, consistent with a mechanism that primarily caps intake rather than also raising expenditure