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It focuses on gradual escalation of NAD dosage, mimicing cellular adaption, and the oral NR/NMN before the IV phase will help to prep NAD salvage pathways
This maintains receptor sensitivity, allows assessment of results, and reduces risk of side effects from prolonged GH elevation
The experts agreed that the choice between sequential and combined therapy largely depends on patient factors such as cardiovascular risk, stages of chronic kidney disease, comorbidities, body weight, and HbA1c levels
Still, it is important not to ignore new or sudden pain
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