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Additionally, semaglutide had a higher efficacy than liraglutide in managing body weight and reducing HbA1c

Since pulmonary aspiration risk is strongly influenced by baseline patient characteristics, factors such as indications for GLP-1 agonist use (e.g., diabetes and obesity) and underlying comorbidities like GERD and autonomic neuropathy may also contribute to the observed heterogeneity

These results suggest that GLP-1 analogs may provide an effective treatment option for patients with MC4R-POMC pathway deficiencies