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Bupropion is an aminoketone antidepressant (the same active ingredient found in Wellbutrin), while naltrexone is an opioid antagonist commonly used to treat alcohol and opioid dependence

Ozempic works by mimicking the action of the naturally occurring hormone GLP-1, which plays a significant role in regulating appetite and managing blood sugar levels

Since then, multiple guidelines and regulatory documents have addressed the issue, including a 1993 guidance on the study and evaluation of gender difference in clinical trial evaluation of drugs, which lifted restriction on participation by most women with childbearing potential (FDA, 1993, 2020b)

GLP-1 RAs, SGLT2 inhibitors, and pioglitazone in addition to understanding putative beneficial synergistic effects in both MASH and other metabolic comorbidities