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Interaction of Neisseria meningitidis carrier and disease isolates of MenB cc32 and MenW cc22 with epithelial cells of the nasopharyngeal barrier
Thymosin beta 4 is also one of few compounds in this class with genuine randomised controlled human data, though in a topical ophthalmic formulation rather than a systemic one, RGN-259 eye drops having been evaluated in placebo-controlled Phase 2 and Phase 3 trials (Sosne et al., Cornea 2015 and Int J Mol Sci 2023)
In 2024 alone, pharmaceutical companies spent $7.7 billion on trials for drug candidates that were ultimately terminated
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