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Growth hormone (GH) has been shown to play a role in the onset of puberty, and it regulates the expression of steroidogenic acute regulatory protein (STAR) and steroidogenesis in progenitor Leydig cells (PLCs) [5]
As dose increases to surpass the amount required to maintain homeostasis, overdose toxicity can ensue
10.1016/J.COPH.2022.102235 106 GuerreraI
Its best to minimize or avoid it, especially during dose adjustments
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