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The mechanism of action of GLP-1RA to promote weight loss mainly includes the reduction of fat deposition through regulation of adipose tissue (lipolysis, fatty acid oxidation, and adipocyte differentiation) and the reduction of food intake through the central and peripheral nervous system
The SURMOUNT-5 trial , as described by Aronne and colleagues, compared tirzepatide (Zepbound) to semaglutide (Wegovy), a mono GLP-1, in 751 adults living with obesity with one weight-related medical issue but without diabetes
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