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The main G protein-coupled receptors which activation appears to cause the release of GLP-1 are: GPRC6A (73), GPR40-41-42-43-93-119-120 (43), GPR142, GHS-R1A (74), Tas1R2-Tas2R3(T1R2-T1R3) (75), GPBAR1 (TGR5), and CasR (76, 77) (Table 1)

This does not mean treatment failed

Managing these effects successfully requires understanding the complete GLP-1 medications treatment process, including when to adjust doses, what symptoms require medical attention, and how to optimize nutrition during the adjustment period

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